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Behavior-genetic analysis and aggression: The mouse as a prototype.

Behavior-genetic analysis is now engaged in transferring both concepts and techniques from genetics to neuro-behavioral sciences. We are far from the Nature vs Nurture debate, Heredity-Environment controversy or computation of the percentages of variance due to genes or to milieu. The aim in the field is to find, to catch, to keep genes, involved either in behaviors or in physiological associated mechanisms. Additions of genes or of a chromosomal region (transgenesis), from 1 species to another (from human to murine genome) started several years ago and has pointed to several genes implicated in behaviors, providing the opportunity to discover the effect of a gene in a quite different genetic context and to test for the physiological pathways from gene to behavior. Accurate mapping strategies (mapping within the smallest confidence interval) is the main challenge in genetics today. Aggression has been selected to illustrate the main advances in this interdisciplinary field of research. (PsycINFO Database Record (c) 2007 APA, all rights reserved)