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Neuronal and behavioral differences between Mus musculus domesticus (C57BL/6JBy) and Mus musculus castaneus (CAST/Ei).

Previous studies have demonstrated that classical inbred strains of laboratory mice do not exhibit large genetic distances when simple sequence repeats are used to test for their polymorphisms, whereas mice from wild origin exhibit high polymorphisms (more than 90%) for these sequences when compared with classical inbred strains of lab mice. The difference between Mus musculus castaneus and C57BL/6J reaches 98% and F-sub-1s males and females are fertile. These 2 properties pave the way for gene mapping derivating segregating generations between these strains. The phenotypical characteristics of Mus musculus castaneus have not been investigated, unfortunately. The 1st screening of Mus musculus castaneus and C57BL/6By was carried out for sensorial and motor development, spontaneous behavior in new environment, paw preference, maternal behavior aggression in 2 different situations, and time to learn escape in a water maze. Morphometry of hippocampus and weight of the male reproductive organs for measures that have been reported to be correlated with several of the examined behaviors are reported. The authors also tested reactivity to 1 drug (β-CCM) revealing seizure proneness. The 2 strains differed for 69% of the reported measures. (PsycINFO Database Record (c) 2007 APA, all rights reserved)